Sep 14th 2014, 00:00, by Daniel A. Lim, Arturo Alvarez-Buylla
Since the discovery of adult brain neurogenesis [1,2], a finding that overturned the long-held notion 'of no new neurons' in the adult central nervous system, exploration into the cellular and molecular regulation of adult neural stem cells (NSCs) has continued to generate fundamental insights into both neural developmental and adult brain function. One of the most interesting questions unique to the study of adult neurogenesis is how adult NSCs – which are derived from progenitor cells in the embryo – retain both their neurogenic capacity and regional specificity for long periods of time.
