AD is a neurological disorder which inflicts a high burden on the caretakers and the society. Neuropathologically, brains of AD patients contain extracellular amyloid plaques composed primarily of Aβ, and intracellular neurofibrillary tangles (NFTs) composed mainly of pathologically aggregated and post-translationally modified Tau (reviewed in [1]). NFTs are located mainly in the somatodendritic compartment of neuronal cells, and abnormally phosphorylated Tau is detectable even before NFTs in the soma and dendrites.
