| Presynaptic long-term depression mediated by G-coupled receptors Aug 23rd 2014, 00:00, by Brady K. Atwood, David M. Lovinger, Brian N. Mathur It is increasingly clear that LTD is crucial for shaping lasting changes in circuit function, learning, memory, and behavior. LTD is often thought of as a mechanism that weakens synaptic strength (see Glossary) [1]. However it is a common misconception that LTD is 'forgetting' and long-term potentiation (LTP) is 'memory'. Several studies now indicate that LTD supports various forms of learning [2–4]. LTD may function as a signal/noise filter because the strongest afferent inputs would have the most influence on postsynaptic neuronal output. |
